An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE).
نویسندگان
چکیده
A 72-year-old Chinese female presented with a rapidly progressing, generalised rash over a 2-week period. Her medical history includes hypertension for which nifedipine had been started 5 weeks earlier. She was otherwise well with no systemic symptoms. Physical examination showed annular, scaly, erythematous plaques with central clearing on her upper and lower limbs, neck, trunk, and back (Figs. 1A and 1B).
منابع مشابه
Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors
Subacute cutaneous lupus erythematosus (SCLE) is an autoimmune disease that may be induced by proton pump inhibitors (PPIs) in at-risk populations. The US FDA does not recognize SCLE as an adverse event associated with PPIs. We queried the FDA Adverse Event Reporting System database, which contains adverse event case reports submitted by the public as well as by industry, and analyzed the data ...
متن کاملTissue eosinophilia: not an indicator of drug-induced subacute cutaneous lupus erythematosus.
OBJECTIVE To investigate whether tissue eosinophilia is a differentiating histopathologic feature of drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) compared with non-DI-SCLE. DESIGN Retrospective medical record review with prospective blinded histopathologic analysis. SETTING University-affiliated dermatology and dermatopathology practice. PATIENTS Fifty-nine patients with ...
متن کاملAnastrozole-induced subacute cutaneous lupus erythematosus.
Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE) has been associated with numerous drugs, but there are limited reports of its association with aromatase inhibitor anastrozole. We report the case of a patient undergoing treatment with anastrozole for breast cancer who presented with clinical, serological, and histological evidence consistent with DI-SCLE. Her condition quickly bega...
متن کاملSubacute cutaneous lupus erythematosus induced by chemotherapy: gemcitabine as a causative agent.
IMPORTANCE Several chemotherapeutic agents have been reported to induce subacute cutaneous lupus erythematosus (SCLE). To our knowledge, this is the first report to date of SCLE induced by monotherapeutic gemcitabine hydrochloride and includes a comprehensive review of all published cases of chemotherapeutic drug-induced SCLE. OBSERVATIONS We describe a patient who developed a SCLE-like erupt...
متن کاملAromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review
Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of the Academy of Medicine, Singapore
دوره 43 8 شماره
صفحات -
تاریخ انتشار 2014